Coronary cytoskeletal modulation of coronary blood flow in the presence and absence of type 2 diabetes: the role of cofilin
BackgroundCoronary resistance microvessels (CRMs) from type 2 diabetic (T2DM) mice and pigs are less stiff compared to normal, a finding that is dictated by less stiff coronary vascular smooth muscle cells (VSMCs).Cofilin is an endogenous actin regulatory protein that depolymerizes filamentous (F)-actin, and portions of F-actin bound to cofilin are